We are ready to help you overcome the challenges of producing and developing innovative biotechnological products and advancing scientific research
Leveraging expertise in advanced protein engineering and bioinformatics, our company possesses the ability to design, optimize, and innovate in the creation of novel enzymes with fully customized properties, utilizing the most powerful computational (in silico) methods
Through the use of advanced algorithms, precise simulations, and molecular modeling, we are able to create enzymes that are optimized for stability, catalytic activity, and compatibility with industrial conditions. The following sections introduce some of our services in this area:
In this method, we reconstruct the ancestral sequences of enzymes by utilizing phylogenetic analyses, statistical evolutionary modeling, and multiple sequence alignment (MSA). The reconstructed enzymes typically possess the following characteristics
High thermal stability due to their similarity to primordial enzymes that evolved in harsh environmental conditions
Broad functional flexibility, enabling activity across a wide range of pH and temperatures
Greater robustness in industrial environments, such as the presence of organic solvents or concentrated salts
This approach helps our clients receive enzymes that deliver exceptional performance not just in laboratory settings, but also on an industrial scale
In chimeric enzyme design, we create hybrid enzymes with unique properties by combining key segments, such as domains or active motifs, from several different enzymes
This method utilizes homology modeling, docking, and molecular dynamics simulation to ensure that the final enzyme structure possesses optimal stability and function. Chimeric enzymes can exhibit specific traits, such as activity toward unusual substrates or resistance to inhibitors, which makes them highly suitable for complex industrial applications
In the Consensus Sequence Design method, our company collects and aligns a large set of homologous sequences to determine the most frequent amino acid at each position
Using this consensus sequence, we design enzymes that exhibit higher thermal and structural stability. This method reduces the likelihood of misfolding errors and improves the overall quality of enzyme performance. Most importantly, this strategy minimizes the need for extensive and costly laboratory experiments while dramatically increasing the efficiency of industrial enzymes. This approach is highly effective for optimizing enzymes at an industrial scale and reducing development costs
We are ready to partner with you in overcoming production challenges, developing innovative biotechnological products, and advancing scientific research
+98 912 836 0916
+98 930 144 1004
nimanezhad86@gmail.com
Custom-optimized rational enzyme engineering for your process requirements
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